Auto Tandem Catalysis: Asymmetric Vinylogous Cycloaddition/Kinetic Resolution Sequence for the Enantioselective Synthesis of Spiro?Dihydropyranone from Benzylidene Meldrum's Acid
نویسندگان
چکیده
A catalytic enantioselective vinylogous domino reaction has been achieved from ketone-derived benzylidene Meldrum's acid and ?-ketolactones to provide spirolactone dihydropyranones with more than 99% ee. An Auto Tandem Catalysis (ATC) process resulting dual complementary role of (DHQ)2PHAL organocatalyst resulted in a sequence involving an asymmetric formal (4+2) cycloaddition the subsequent kinetic resolution operating through 1,3-prototropic shift leading good yields (>50%) high selectivity.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2021
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202100559